William P. Purcell, PhD

Chairman and CEO

Founder

William P. Purcell, Ph. D., the founder and majority shareholder of MDI, serves as its president and Chief Executive Officer.  In addition, Dr. Purcell also serves as Chief Operating Officer and Director of Research and Development.

He has had a distinguished career as a Professor of Medicinal Chemistry at The University of Tennessee (Memphis) and currently serves as an adjunct member of the Graduate Faculty, Department of Chemistry, at the University of Memphis.

Dr. Purcell has extensive experience in drug design, and has an international network of collaborators.

Recognition

International Directory of Research and Development Scientists, Institute for Scientific Information, Philadelphia, PA (1969).

American Men and Women in Science, 12th edition, The Physical and Biological Sciences, Jaques Cattel Press, R. R. Bowker Company, New York, NY (1973).

Personalities of the South, 6th edition, American Biographical Institute, Raleigh, NC (1973).

The World of Learning, 24th edition, Europa Publications Ltd., London, England (1973).

Who’s Who in America, 38th edition, Marquis Who’s Who, Chicago, IL, Von Hoffman Press, Inc., St. Louis, MO (1974).

The National Register of Prominent Americans and International Notables.

Who’s Who in the South and Southwest, 14th edition.

Education

Indiana University, A.B., 1957 Princeton University, A.M., 1959

   Major:  Chemistry           Ph.D., 1960

   Minors:  Mathematics and German   Major:  Physical Chemistry

Qualified in Organic, Inorganic, and Analytical Chemistry

Postgraduate Training

Polytechnic Institute of Brooklyn, X-Ray School, Professor I. Fankuchen, 1961.

RS/1 training, BBN, Cambridge, 1986.

Financial Support for Education

Indiana University: academic scholarship, proctor, and synthetic organic research

Princeton University: teaching assistantship (1957-1958), research assistantship (1958-1959).  Allied Chemical Fellowship (1959-1960), NSF Summer Fellowship 1960.

Predictions

PREDICTION OF ACTIVITY OF A COMPOUND THAT DID NOT EXIST

W.P. Purcell, “Cholinesterase Inhibitory Prognoses of Thirty-Six Alkyl Substituted 3-Carbamoylpiperidines,” Biochimica et Biophysica Acta, 105:201-204, 1965.

PRESENTATION OF PREDICTION

International Conference on Structure and Reactions of DFP-Sensitive Enzymes, 1966, Stockholm, Sweden.

PROOF OF THE ACCURACY OF THE PREDICTION

J.G. Beasley and W.P. Purcell, “An Example of Successful Prediction of Cholinesterase Inhibitory Potency From Regression Analysis,” Biochemical Biophysica Acta, 178:175-176, 1969.

Professional Memberships

Alpha Chi Sigma

American Chemical Society

Fellow, American Association of Pharmaceutical Sciences

Fellow, American Pharmaceutical Association Academy of Pharmaceutical Sciences

Fellow, The Chemical Society

International Society of Quantum Biology, Cofounder (1969-present)

Rho Chi Society, Faculty Adviser (1964-1967)

Society of the Sigma Xi

Publications

Dr. Purcell is a recognized expert in the field of molecular modeling and is a pioneer in Quantitative Structure-Activity Relationships (QSAR) with his book, a first in this area:

  • “Strategy of Drug Design:  A Molecular Guide To Biological Activity” (John Wiley and Sons, New York, 1973).

Dr. Purcell is co-founder of the quarterly publication QSAR Including Molecular Modeling and Applications of Computer Graphics.  He has regularly contributed articles on the application of QSAR techniques to drug design and development to scholarly publications, including Journal of Medicinal Chemistry, Journal of Pharmaceutical Sciences, and Molecular Pharmacology.

  • “Dielectric Relaxation Times and Structures of Some Nonrigid Molecules.”  Ph.D. Thesis, Princeton University, 1960.

Articles
  1. H.A. Pohl, R. Bacskai, and W.P. Purcell, “Steric Order and Dielectric Behavior in Polymethylmethacrylates,” Journal of Physical Chemistry, 64:1701-1705, 1960.
  2. W.P. Purcell and C.P. Smyth, “The Dielectric Relaxation of a Polyester of 1,2-Propylene Glycol and Adipic Acid in Solution,” Journal of Polymer Science 47:321-325, 1960.
  3. W.P. Purcell, K. Fish, and C.P. Smyth, “The Relaxation of the Methylene Chloride Group in Three Aromatic Molecules,” Journal of the American Chemical Society, 82:6299-6301, 1960.
  4. W.E. Vaughan, W.P. Purcell, and C.P. Smyth, “The Relaxation Times of Spherical Polar Molecules in Carbon Tetrachloride Solution,” Journal of the American Chemical Society, 83:571-576, 1961.
  5. W.P. Purcell and C.P. Smyth, “The Effect of Structural Factors upon Group Rotation in Some Aromatic Molecules,” Journal of the American Chemical Society, 83:1060-1063, 1961.
(Read more…)

Short Courses and Presentations

Institute in Quantum Chemistry, Solid State Physics, and Quantum Biology, 1966, 1968-1976, 1978-1981, Sanibel Island, Florida.

Walter Reed Army Institute of Research, Department of Molecular Biology, Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action, 1970, Washington, D.C.

Gordon Research Conference on Medicinal Chemistry, section on Theoretical Chemistry and Drug Design, “New Work on the Correlation of Electronic Structure and Physicochemical Parameters with Biological Activity,” August 9-13, 1971, Colby Jr. College, New London, New Hampshire.

Keynote address presented at the Prague Conference on Chemical Structure-Biological Activity Relationships:  Quantitative Approaches, under the auspices of the Czechoslovak Medical Society, J.D. Purkyne, Institute of Hygiene and Epidemiology, Department of Industrial Hygiene and Occupational Diseases, the Czechoslovak Chemical Society, and the International Society of Quantum Biology, June 26-29, 1973, Prague, Czechoslovakia.

The VIIth Jerusalem Symposium, “Molecular and Quantum Pharmacology,” sponsored jointly by the Hebrew University, Jerusalem, Israel, and the Institute de Biologie Physico-Chimique (Foundation Edmond de Rothschild), Paris, France, and presented lecture “Quantitative Structure-Activity Relationships:  An Approach to Drug Design,” March 25-April 4, 1974, Jerusalem, Israel.

(read more…)

Let's Talk About Your Project

Molecular Design International, Inc.

changing the world,
one molecule at a time
© 2016 Molecular Design International, Inc.
Connect and Follow
1138 North Germantown Parkway
Suite 105-152
Cordova, TN 38016
Phone (901) 747-3366
Fax (901) 747-5606
Privacy Policy
Terms of Use

Website Design by barker.digital