William P. Purcell, PhD
Chairman and CEO
William P. Purcell, Ph. D., the founder and majority shareholder of MDI, serves as its president and Chief Executive Officer. In addition, Dr. Purcell also serves as Chief Operating Officer and Director of Research and Development.
He has had a distinguished career as a Professor of Medicinal Chemistry at The University of Tennessee (Memphis) and currently serves as an adjunct member of the Graduate Faculty, Department of Chemistry, at the University of Memphis.
Dr. Purcell has extensive experience in drug design, and has an international network of collaborators.
International Directory of Research and Development Scientists, Institute for Scientific Information, Philadelphia, PA (1969).
American Men and Women in Science, 12th edition, The Physical and Biological Sciences, Jaques Cattel Press, R. R. Bowker Company, New York, NY (1973).
Personalities of the South, 6th edition, American Biographical Institute, Raleigh, NC (1973).
The World of Learning, 24th edition, Europa Publications Ltd., London, England (1973).
Who’s Who in America, 38th edition, Marquis Who’s Who, Chicago, IL, Von Hoffman Press, Inc., St. Louis, MO (1974).
The National Register of Prominent Americans and International Notables.
Who’s Who in the South and Southwest, 14th edition.
Indiana University, A.B., 1957 Princeton University, A.M., 1959
Major: Chemistry Ph.D., 1960
Minors: Mathematics and German Major: Physical Chemistry
Qualified in Organic, Inorganic, and Analytical Chemistry
Polytechnic Institute of Brooklyn, X-Ray School, Professor I. Fankuchen, 1961.
RS/1 training, BBN, Cambridge, 1986.
Financial Support for Education
Indiana University: academic scholarship, proctor, and synthetic organic research
Princeton University: teaching assistantship (1957-1958), research assistantship (1958-1959). Allied Chemical Fellowship (1959-1960), NSF Summer Fellowship 1960.
PREDICTION OF ACTIVITY OF A COMPOUND THAT DID NOT EXIST
W.P. Purcell, “Cholinesterase Inhibitory Prognoses of Thirty-Six Alkyl Substituted 3-Carbamoylpiperidines,” Biochimica et Biophysica Acta, 105:201-204, 1965.
PRESENTATION OF PREDICTION
International Conference on Structure and Reactions of DFP-Sensitive Enzymes, 1966, Stockholm, Sweden.
PROOF OF THE ACCURACY OF THE PREDICTION
J.G. Beasley and W.P. Purcell, “An Example of Successful Prediction of Cholinesterase Inhibitory Potency From Regression Analysis,” Biochemical Biophysica Acta, 178:175-176, 1969.
Alpha Chi Sigma
American Chemical Society
Fellow, American Association of Pharmaceutical Sciences
Fellow, American Pharmaceutical Association Academy of Pharmaceutical Sciences
Fellow, The Chemical Society
International Society of Quantum Biology, Cofounder (1969-present)
Rho Chi Society, Faculty Adviser (1964-1967)
Society of the Sigma Xi
Dr. Purcell is a recognized expert in the field of molecular modeling and is a pioneer in Quantitative Structure-Activity Relationships (QSAR) with his book, a first in this area:
“Strategy of Drug Design: A Molecular Guide To Biological Activity” (John Wiley and Sons, New York, 1973).
Dr. Purcell is co-founder of the quarterly publication QSAR Including Molecular Modeling and Applications of Computer Graphics. He has regularly contributed articles on the application of QSAR techniques to drug design and development to scholarly publications, including Journal of Medicinal Chemistry, Journal of Pharmaceutical Sciences, and Molecular Pharmacology.
“Dielectric Relaxation Times and Structures of Some Nonrigid Molecules.” Ph.D. Thesis, Princeton University, 1960.
H.A. Pohl, R. Bacskai, and W.P. Purcell, “Steric Order and Dielectric Behavior in Polymethylmethacrylates,” Journal of Physical Chemistry, 64:1701-1705, 1960.
W.P. Purcell and C.P. Smyth, “The Dielectric Relaxation of a Polyester of 1,2-Propylene Glycol and Adipic Acid in Solution,” Journal of Polymer Science, 47:321-325, 1960.
W.P. Purcell, K. Fish, and C.P. Smyth, “The Relaxation of the Methylene Chloride Group in Three Aromatic Molecules,” Journal of the American Chemical Society, 82:6299-6301, 1960.
W.E. Vaughan, W.P. Purcell, and C.P. Smyth, “The Relaxation Times of Spherical Polar Molecules in Carbon Tetrachloride Solution,” Journal of the American Chemical Society, 83:571-576, 1961.
W.P. Purcell and C.P. Smyth, “The Effect of Structural Factors upon Group Rotation in Some Aromatic Molecules,” Journal of the American Chemical Society, 83:1060-1063, 1961.